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Postdoctoral fellow, organoid engineering and characterization (starting May 2021, 2 years)
Entreprise:F. Hoffmann-La Roche AG, Employeur direct
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Description du poste↓Profil de l'employeur↓
Date de publication10.04.2021
Numéro de référence202102-104160
Domaine d'activité
Recherche/ Développement
Lieu de travail***CH Suisse/ Schweiz/ Switzerland***, 4070 Basel
Expérience professionnelle réquisenon
Diplôme universitairePhD
Brève descriptionAt Roche Pharmaceutical Research and Early Development Organization (pRED), we believe that rapid advances in science, technology, and Big Data are our greatest opportunity to rethink the way we address some of the world's most challenging unmet health needs and have an even more profound impact on patients and society.
Description complèteThe Postdoctoral Fellow in Organoid Engineering will work at the Institute for Translational Bioengineering (ITB), a newly formed scientific group in pRED whose goal is to disrupt the traditional drug discovery process through innovation/big and bold ideas focused on improving our ability to use predictive human model systems. He/she will play a key role in ITB's efforts to develop and apply next generation human organoids and organs-on-a-chip.

Your responsibilities are

- Collaborate with internal and external partners to drive a project focused on reproducing the tumor microenvironment in patient-derived organoids and applying them to precision cancer therapy
- Apply advanced single-cell and spatial omics approaches to characterize various organoid-based cancer models, increase their pathophysiological relevance and expand their translational value
- Generate high-quality results for peer-reviewed publications and present at scientific meetings

Who you are

You are a scientist with a PhD in the field of immunology or immuno-oncology with profound understanding of the tumor microenvironment and several years of experience in applying omics approaches to answer complex biological questions. You are intellectually brave and adept at applying your skills to new fields to generative innovative and transformative insights. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.

The position would require advanced expertise in

- Sample preparation, generation, analysis and interpretation of single cell and spatial omics (transcriptomics, proteomics) data
- Multi-color microscopy and immune phenotyping by flow cytometry (>12 markers)
- Computational approaches and programming languages (e.g. C, R, Matlab)
- Basic immunological assays
- Isolation of peripheral and tissue-resident immune cells
- Primary cell cultures and basic molecular and cell biology techniques

The following experiences would be considered an asset

- 3D culture (e.g. organoids, spheroids)
- Microfluidics and microphysiological systems
- High-throughput image processing and analysis
- Isolation of epithelial cells from human tissues including cell sorting
- Cancer immunotherapy

The preferred start date is May 2021.

To be considered your application needs to include

A cover letter, a CV (including a list of relevant publications) and the names of three references

Are you ready to apply? We are looking for someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche. When applying for this position, already project yourself in the future. Think about what could come next and how you would like to build your future.

Roche embraces diversity and equal opportunity in a serious way. We are dedicated to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq


Who we are

At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.
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